In a recent episode of his HBO Max comedy series, Larry David takes on the role of Dora Salk, mother of polio vaccine developer Jonas Salk, in a 1950s-set scene where he defends vaccination against a dismissive neighbour who compares immunisation to Nazi plots and warns vaccines will cause heart attacks. David's character responds with withering insults, ridiculing the neighbour as ignorant and unfit for any position of influence. The sketch functions as satirical commentary on vaccine misinformation and public health scepticism.

The neighbour character appears designed to reference Robert F. Kennedy Jr., who has been a prominent anti-vaccine activist and is married to actress Cheryl Hines—David's former on-screen wife during their years on Curb Your Enthusiasm. David, known as an outspoken Trump critic, apparently views Kennedy's vaccine advocacy unfavourably enough to incorporate into his comedy. Notably, Hines has not participated in David's new programme, and reporting suggests their personal friendship has cooled considerably in recent years.