Charlize Theron has reflected negatively on *Æon Flux*, the 2005 science-fiction film adapted from the animated series, describing it as a project whose potential was squandered. Her comments underline the difficulties of turning a distinctive cult property into a mainstream studio film, and the lasting disappointment she associates with its final result.

Theron starred as the title character in the futuristic action film, which was directed by Karyn Kusama and set in a post-pandemic dystopia. Despite its prominent cast, ambitious premise and substantial production, the film was poorly received and became a notable commercial and critical disappointment.