San Diego Comic-Con hosted a Star Trek panel in Hall H to mark the franchise's 60th anniversary, bringing together actors from across its many series, including George Takei from the original 1966 show alongside cast members from The Next Generation, Deep Space Nine, Voyager, Enterprise, Discovery, Picard, Lower Decks, Strange New Worlds and Starfleet Academy. The event underlines Star Trek's remarkable longevity and cultural reach, even as its future on television remains uncertain beyond already-completed seasons of Strange New Worlds and Starfleet Academy, with a new film in development but no other series yet confirmed.

Panellists including Michael Dorn, Doug Jones, Jerry O'Connell, Karim Diané and Takei himself reflected on the show's enduring legacy and fan devotion, sharing personal anecdotes such as a fan's tattoo of Diané's character and a supportive text from Wil Wheaton to O'Connell on joining the franchise. Several actors praised creator Gene Roddenberry for the show's progressive, multicultural bridge crew when it launched in 1966, crediting it with offering audiences an optimistic vision of the future that has sustained the franchise across generations.