England's upcoming World Cup fixture against Mexico in Mexico City presents a physiological challenge due to the venue's high elevation. Research indicates that sildenafil, commonly known as Viagra, may help mitigate some of the adverse effects athletes experience at altitude, such as reduced oxygen availability and increased cardiovascular stress.

The altitude advantage traditionally favours teams accustomed to playing at elevation, giving Mexico an edge at home. If England were to consider such performance interventions within regulatory limits, it could potentially help offset Mexico's environmental advantage and provide their players with better oxygen utilisation during the match.