A routine physical led Louisiana musician Joseph Wayne Singleton to an unexpected prostate cancer diagnosis at 33, despite having no symptoms and being younger than the usual screening age. The early detection allowed him to undergo surgery and recover quickly, prompting him to advocate for screening when clinically appropriate.

Singleton’s PSA level was exceptionally high, and a biopsy confirmed cancer; doctors at MD Anderson reportedly had not seen prostate cancer in someone so young. Screening guidance varies, with some organisations suggesting discussions from 45 for average-risk men, while higher-risk groups—including Black men and those with a family history—may be advised to start at 40–45. Recommendations also differ on testing intervals and when screening should stop.