Eddie Vedder, the Pearl Jam frontman, has spoken about the powerful effect of Fugazi's 1987 song "Give Me the Cure", describing it in terms usually reserved for narcotics. His comments came during a wider discussion of punk's influence on grunge, a genre he helped popularise, and how bands that never achieved mainstream success still shaped rock music profoundly.

Vedder explained that "there's certain songs that, just the sound of them is like a drug," singling out Fugazi's track for its distinctive blend of aggression and melody. He also praised the Ramones for maintaining the same intensity across 22 years together, contrasting their longevity with the shorter-lived but equally influential burst of energy that defined both punk and grunge movements.