Demi Moore has revealed that she felt out of place while filming Charlie's Angels: Full Throttle in 2003, describing how she was heavily scrutinised over her appearance during a bikini scene. Speaking during a career resurgence prompted by her acclaimed role in The Substance, Moore reflected on a difficult period in the early 2000s when Hollywood's ageism limited the roles available to her as a woman in her forties, no longer viewed as a 1990s icon but not yet cast in more mature parts either.

In the film, Moore played villain Madison Lee opposite the trio of Cameron Diaz, Drew Barrymore and Lucy Liu, and said she felt objectified by the constant focus on her looks rather than her performance. The production was already troubled, with Bill Murray declining to return after a reported feud with Liu on the first film, and although Full Throttle grossed nearly as much as its 2000 predecessor, its $30 million cost and high salary demands scuppered plans for a third instalment. Despite a mixed critical legacy, the film retains a cult following, particularly among young female and queer audiences, in contrast to the poorly received 2019 reboot.