James Cameron has spoken out against the dominance of superhero films, saying in a resurfaced 2018 interview with IndieWire that he hopes for "Avenger fatigue" and believes cinema needs more variety beyond stories about, in his words, "hypergonadal males" saving the world. The comments, made around the release of Avengers: Infinity War, highlight a broader debate about franchise fatigue in Hollywood and the outsized influence Marvel has had on modern blockbuster filmmaking.

Cameron made the remarks as the Marvel Cinematic Universe's Infinity Saga built towards its climax with Infinity War and Endgame, after which interest in superhero films did begin to wane, driven by cast departures, an overload of spin-off content, and audience appetite for something new. The article notes an irony in Cameron's stance, given that his own Avatar franchise has been criticised for repetitive storytelling, and questions whether more Avatar sequels are really the solution to Marvel-driven franchise fatigue.