# USC vs. Indiana odds, picks, predictions: Spread analysis and best bets for Big Ten duel

- URL: https://talkfuse.com/story/usc-vs-indiana-odds-picks-predictions-spread-analysis-and-best-bets-for-big-ten-duel/
- Published: 2026-11-14T16:00:00+00:00
- Updated: 2026-11-14T16:22:42+00:00
- Original publisher: New York Post (publisher lean: Right)
- Original article: https://nypost.com/2026/11/14/betting/usc-vs-indiana-odds-picks-predictions-college-football-best-bets-week-11/
- Topics: Entertainment, TV, World

## Key points

- Indiana are 8.5-point favourites over USC.
- Both teams need a win to bolster playoff hopes.
- The article recommends betting under 50.5 points.

## Summary

No. 6 Indiana hosts No. 15 USC in a Big Ten game with both teams needing a win to strengthen their College Football Playoff hopes. The article predicts a low-scoring contest, citing Indiana’s strong defence and recent offensive struggles, alongside USC’s uneven form.

Indiana is an 8.5-point favourite after going 8-1, but several conference wins have been close and the team has unsettled quarterback options. USC is 7-2 and gained 6.8 yards per play against Ohio State, after managing 3.2 against Wisconsin. The recommended bet is under 50.5 total points at -110.

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Summarised by TalkFuse (https://talkfuse.com/). Quote the original publisher for the reporting and link this page for the summary and discussion.