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Pathogenic game Parasites tier list: Best ones to use
This Destructoid guide ranks the playable parasites in the indie game Pathogenic, where players control a microscopic organism attempting to overrun the human body and reach the brain for the "true ending". The author sorts available parasites into S, A and B tiers based on how easily they let a run progress toward the advanced organs, offering newcomers a quick reference for which options give the best chance of success.
The Amoeba and Helminth top the S-tier thanks to reduced DNA levelling costs and strong defensive blocking respectively, while the beginner-friendly Bacterium and shop-discounting Lil Collector sit in A-tier. The Fungal Spore and two-player co-op Diatom round out B-tier, held back by limited manoeuvrability and reliance on a second player and controller; the writer notes the Nanobot parasite remains unranked as it has yet to be unlocked.
In short
- Destructoid ranks Pathogenic's playable parasites into S, A and B tiers.
- Amoeba and Helminth are rated the strongest, S-tier choices.
- Diatom requires two co-op players; Nanobot remains unranked/unlocked.
Explained simply
Pathogenic is an indie game in which players control a microscopic organism attempting to infiltrate a human body and reach the brain. The gameplay involves navigating through different organs whilst managing resources and overcoming biological defences, with the ultimate goal of reaching the brain to unlock the game's true ending.
Guides that rank playable options by effectiveness, known as tier lists, help new players understand which choices offer the best chance of success. In Pathogenic, players can select from different types of parasites, each with distinct abilities and characteristics that affect how easily they can progress through the human body.
The game offers several parasite options, ranging from straightforward choices suited to newcomers to more specialised ones that require particular strategies or additional resources. Each parasite has different strengths and weaknesses, with some offering advantages in cost or defence, whilst others may be constrained by limited movement or the need for a second player.