Spider-Man: Brand New Day has recorded the highest-grossing domestic opening weekend in box office history, an achievement being framed as a decisive end to the years-long slump often described as "superhero fatigue." The Sony-Marvel film's success is notable because it surpassed 2019's Avengers: Endgame, which had previously held the domestic opening record and marked the symbolic close of the Marvel Cinematic Universe's most successful era before the pandemic-era slowdown in comic book film performance. Analysts point to several factors behind the result, including the consistently strong track record of Tom Holland's Spider-Man films and the movie's more grounded, character-driven tone compared with recent effects-heavy superhero releases.

The film grossed $360 million domestically and $572 million internationally, for a global opening of $932 million. While other post-Endgame releases such as The Batman, Superman, Black Panther: Wakanda Forever, Guardians of the Galaxy Vol. 3 and Deadpool & Wolverine had performed well, only Deadpool & Wolverine had crossed the billion-dollar mark among non-Spider-Man Marvel titles. Commentators credit the film's director, Destin Daniel Cretton, with delivering a slower-paced, more dramatic style than typical Marvel blockbusters, contrasting it with recent underperforming films like Supergirl and Fantastic Four, which relied heavily on computer-generated spectacle.