Alzheimer’s could begin in nose as charity says ‘researchers interested’

Researchers are investigating whether the nose could offer early clues about Alzheimer’s or play a role in the disease’s development. The idea has drawn attention because the nose is closely connected to the brain, but current evidence does not show that Alzheimer’s begins there.

Studies described by mathematician Hannah Fry found brain inflammation and plaque-like changes after mice were exposed nasally to a bacterium, and similar findings in dogs exposed to polluted air. Alzheimer’s Research UK says smell changes can precede symptoms by years, while scientists explore smell tests, nasal samples and nose-delivered medicines. The charity stresses that more research is needed before these approaches can guide routine care.