Houston vs. Colorado odds, picks, predictions: Smart betting angles for late-night Big 12 tilt

Houston, ranked 14th, visits Colorado on Friday as a 9.5-point favourite, with the Cougars looking to strengthen a slim College Football Playoff case. The article’s betting pick is for the teams to score more than 51.5 points, arguing that Houston’s efficient attack and Colorado’s defensive matchup could produce a high-scoring game.

Houston is 7-2 overall and 4-2 in the Big 12, while Colorado is 3-6 and 1-5. Houston’s two losses were narrow defeats away to top-10 teams, and it leads FBS in third-down conversion rate while averaging more than five yards per carry. The article notes Houston’s defensive weaknesses and Colorado’s struggles on offence, and recommends the Over at 51.5 points, priced at -110 with DraftKings.