Comedian Larry David's new HBO series features a comedy sketch that directly targets U.S. Health Secretary Robert F. Kennedy Jr. and his vaccine skepticism. In the episode, David performs in drag as the mother of polio vaccine inventor Jonas Salk, whilst another character argues that vaccines cause serious harm—prompting David's character to deliver a cutting remark questioning the competence of incompetent leadership.

The sketch reflects a deteriorated friendship between David and Kennedy, who were previously acquainted after David introduced Kennedy to actress Cheryl Hines (now Kennedy's wife). Their relationship reportedly soured following Kennedy's association with the current administration. The comedy series has established itself as a platform for political satire, having previously featured sketches criticising President Trump.