Entertainment site Collider has published a speculative feature by writer Michael Block listing ten Marvel heroes, allies or teams considered powerful enough to defeat Doctor Doom. The article is framed around the upcoming film Avengers: Doomsday, in which Robert Downey Jr. is set to play a new version of Doctor Doom, marking his return to the Marvel Cinematic Universe following his previous role as Iron Man. The piece taps into significant fan anticipation ahead of the film's release later in the year.

The author stresses that the list is not a prediction of the film's plot, and that not all the characters featured will necessarily appear. Instead, it draws on precedents from earlier films, comics and series, as well as each character's powers and track record. The entries reviewed cover mystical, intellectual and brute strength, and include Captain Marvel (Brie Larson), whose cosmic energy abilities and role in defeating Thanos are highlighted; Doctor Strange (Benedict Cumberbatch), positioned as a strong contender in a magical duel and confirmed to return; and the Fantastic Four, Doom's traditional adversaries, played in the MCU by Pedro Pascal, Vanessa Kirby, Ebon Moss-Bachrach and Joseph Quinn.