New England Patriots wide receiver A.J. Brown left his debut for the team early after appearing to suffer an ankle injury during the third quarter of the NFL season opener against the Seattle Seahawks. The match, a rematch of Super Bowl LX, which Seattle had won 29-10 in February, marked a high-profile start to Brown's Patriots career, making his early exit a significant setback for the team just as the new season got under way.

Brown was hurt after a Seattle defender rolled into him while he attempted a catch at Lumen Field, and though he stayed down briefly, he walked to the sideline unaided before being taken to a medical tent and then the locker room wearing only one cleat. He was subsequently ruled out for the rest of the game, finishing with three catches for 26 yards and drawing a 34-yard pass interference penalty that helped set up New England's opening touchdown. The Patriots led 10-3 heading into the fourth quarter, while Seattle also lost starting quarterback Sam Darnold to injury in the first quarter, with Drew Lock replacing him.