Carlos Alcaraz will begin his US Open title defence against Russia’s Roman Safiullin after more than four months without a competitive singles match because of a wrist injury. The draw is significant because it tests whether the defending champion is fit to contend again, while Novak Djokovic starts another attempt to win a record 25th Grand Slam singles title.

Britain’s Arthur Fery faces a difficult opening match against 13th seed Lorenzo Musetti after his breakthrough Wimbledon run lifted him into the world’s top 40. Alexander Zverev is the top men’s seed following Jannik Sinner’s knee-injury withdrawal, while women’s champion Aryna Sabalenka plays Camila Osorio; Katie Boulter, Cameron Norrie and Jan Choinski also feature among the British entrants.