A Destructoid guide compiles a list of items found in Mortal Shell 2, explaining what each one does and how players can use it. The piece is aimed at players wanting to understand their inventory, distinguishing between items that can be equipped as permanent build additions and those that are simply sold for in-game currency.

The guide categorises items as either "Equipable", "Resource", "Treasure" or "Mechanic". Equipables such as Bloodseed and Burnt Effigy heal specific status ailments, while resources like Coin, Glimpse and Gloom are used to purchase upgrades. Treasure items, including the Coin of Mammon and Tooth of Nochte, exist purely to be sold for amounts ranging from 100 to 2,000 coins. The author notes the guide is a work in progress, with some items, such as Trollweed, still not fully understood.