This Destructoid guide ranks all 16 weapons in Mortal Shell 2, split across two categories, to help players identify the most effective options against the game's bosses and enemies. The author groups weapons into S-tier, A-tier and B-tier bands based on damage, versatility across different shells and overall combat utility, offering readers a quick reference for building an effective loadout.

S-tier picks include the Axe and Dagger, Black Needle, Axatana, Salvaged Trebuchaxe and Caged Hystrix, praised for strong damage, useful combos and compatibility with multiple shells. A-tier weapons such as The Iconoclast, Clockwork Scythe, Great Martyr's Blade, Triarch Repeater, Ballistazooka and Forgotten Crossbow are solid but more situational, while B-tier entries like the Veteran's Battle Axe, Obsidian Hammer and Troubadour's Lute are hampered by slow attacks or narrow build requirements. The author notes two weapons, the Naylshotte and Cursed Child, have yet to be fully assessed.