Prime Video's Blade Runner 2099, a 10-episode miniseries premiering on 25 November, sees showrunner Silka Luisa expand the franchise 50 years beyond Denis Villeneuve's 2017 film Blade Runner 2049 and 80 years after Ridley Scott's original 1982 classic. Speaking to Polygon ahead of the launch, Luisa discussed the challenge of creating fresh science fiction within a genre so thoroughly shaped by Scott's original, and explained how producer Alcon Entertainment insisted the series stand apart from the films while remaining within the same canon, giving her creative freedom to tell a standalone story.

The series imagines a future in which replicants have overtaken humans as Earth's dominant species, with Michelle Yeoh playing Olwen, an ageing replicant aware her time is running out, and Hunter Schafer as Cora, a human posing as a replicant to survive. Luisa confirmed Harrison Ford will not appear, distancing the show further from the films' established characters, and described working closely with Alcon and Scott to shape a visually distinct dystopian Los Angeles that avoids simply imitating earlier Blade Runner aesthetics.