Bombanana! is a three-player co-operative puzzle game in which each participant takes on the role of a monkey with a sensory limitation – deaf, mute or blind – and must communicate to defuse a bomb before time runs out. A walkthrough for the game's early stages sets out how the three players should share information to solve each puzzle type, since none of them can see or hear everything needed to complete a task alone. This teamwork mechanic, reminiscent of games such as Keep Talking and Nobody Explodes, is central to the challenge and becomes more demanding as players advance through the game's levels.

The full game contains 30 levels of increasing difficulty, plus an Infinite mode, though the guide focuses on the standard levels. The first five stages introduce distinct puzzle types: a wire-cutting challenge based on cable colour and count; a colour-slider puzzle requiring a precise sequence of moves; a combination of both; a slider-and-direction puzzle involving Braille numbers only the "blind" player can see; and a calculator puzzle requiring the "deaf" and "blind" players to solve an equation before a final digit is determined by a light bulb's colour and whether the answer is odd or even. Although specific colours, numbers and patterns vary between playthroughs, the guide notes that the underlying method for solving each puzzle type remains consistent.