Week two of the NFL saw defences reassert themselves after an offensive feast in week one, with the Chicago Bears suffering a dramatic 56-point swing from their week-one blitz as they fell 9-3 to Minnesota. More concerning than their scoring collapse was the loss of star quarterback Caleb Williams to a hamstring injury, which came just after rival second-overall pick Jayden Daniels was sidelined by an elbow injury, raising troubling questions about two of the league's brightest young talents. Meanwhile, the Kansas City Chiefs demonstrated they remain formidable championship contenders, orchestrating another masterclass in tight-game control with an overtime victory.

The Bears' 59-point week-one outburst gave way to a thoroughly scoreless performance, the second-worst point differential in NFL history. Caleb Williams was carried off in the fourth quarter with a hamstring injury, though early reports suggested it may not be as severe as initially feared; Jayden Daniels suffered a more concerning elbow injury in Washington's loss to Dallas that looks likely to sideline him for an extended period. The Chiefs beat the Colts 33-30 in overtime, with Patrick Mahomes throwing three touchdowns and recording 382 passing yards—his most in three years—as he showed no ill effects from his surgically repaired knee. Other highlights included Green Bay erasing a 10-point deficit to beat New York 20-17 in overtime, Seattle extending their winning streak to 12 games with a 31-7 demolition of Arizona, San Francisco remaining unbeaten after a 35-15 rout of Miami, and Cincinnati defeating Houston 20-6.