Vice President JD Vance delivered a convention keynote address marking one year since Turning Point USA co-founder Charlie Kirk's assassination, framing the November midterms as a battle over what he termed Americans' "birthright". Vance linked his personal life – including the July birth of his fourth child, Alec – to a broader argument about family, jobs, education and homeownership, while launching sharp attacks on Democrats ahead of the election. The speech closed a two-day event intended to energise Republican voters, with Vance speaking immediately before Trump's closing remarks.

Vance recalled Kirk's message about the importance of family and fatherhood, then accused Democratic candidates of undermining the nuclear family, citing an unnamed Michigan candidate's remarks. He also responded to a protester who displayed Mexican and Palestinian flags with a dismissive retort, criticised the economic legacy of the Biden administration on housing and jobs, and touted his fraud task force's discovery of $250 billion in fraud. He further singled out Michigan Senate candidate Abdul El-Sayed over past comments about his family.