This Destructoid guide ranks the playable parasites in the indie game Pathogenic, where players control a microscopic organism attempting to overrun the human body and reach the brain for the "true ending". The author sorts available parasites into S, A and B tiers based on how easily they let a run progress toward the advanced organs, offering newcomers a quick reference for which options give the best chance of success.

The Amoeba and Helminth top the S-tier thanks to reduced DNA levelling costs and strong defensive blocking respectively, while the beginner-friendly Bacterium and shop-discounting Lil Collector sit in A-tier. The Fungal Spore and two-player co-op Diatom round out B-tier, held back by limited manoeuvrability and reliance on a second player and controller; the writer notes the Nanobot parasite remains unranked as it has yet to be unlocked.