The Wall Street Journal has published an investigation detailing alleged procedural failures by Pima County law enforcement in their handling of Nancy Guthrie's disappearance, which began in February 2026. According to the report, investigators overlooked biological evidence at the scene initially, with blood later confirmed through DNA analysis to belong to the missing woman. Additionally, the publication claims law enforcement failed to properly secure the residential property, permitting media personnel, delivery workers, and others to access the area. The investigation also raised questions about leadership decisions, noting that the homicide sergeant overseeing the case had previously faced discipline for investigative missteps in an unrelated matter.

Sheriff Chris Nanos has contested the WSJ's reporting, stating the department continues active work with partner agencies on the investigation. The case has gained national attention partly due to Savannah Guthrie, a prominent television host and Nancy's daughter, who has used social media platforms to appeal for her mother's safe return and directly address those responsible for her disappearance. The department has not yet publicly addressed the specific allegations raised in the investigation, though the sheriff maintains the case remains open and active rather than cold.