Johnny Knoxville appeared as a celebrity guest picker on ESPN's College Gameday coverage from Knoxville, Tennessee, delivering crude and provocative commentary throughout his game selections. Dressed in a Tennessee Volunteers uniform, his remarks prompted visible shock from the on-air talent, including Pat McAfee and Kirk Herbstreit, who repeatedly reacted with disbelief to his statements.

During the programme, Knoxville made several inflammatory remarks whilst selecting winners between matchups. He joked about enduring Pat McAfee's music as self-punishment if Missouri lost, compared Georgia and Oklahoma to sexually transmitted diseases, likened LSU coach Lane Kiffin to toe fungus on flip-flops, and made a crude wordplay joke suggesting Texas represented a urinary tract infection rather than the university. He additionally joked about attempting to bribe a referee with twenty dollars.