The Disney+ animated series X-Men '97 has cast voice actor Erika Ishii as Lady Deathstrike, marking the character's debut in the show's second season. She appears in an episode centred on Wolverine's mission to infiltrate a Weapon X facility, where Logan encounters various antagonists from his past including Sabretooth and Maverick.

Lady Deathstrike's introduction carries narrative weight given her decades-long rivalry with Wolverine stemming from their shared connection to the adamantium enhancement program. The episode simultaneously marks a turning point for the protagonist, as Logan recovers his adamantium skeleton after an entire season without it—a development that resolves a plot thread many expected to extend further. Ishii brings experience from major video game and animation projects including Mortal Kombat 1 and Dragon Age: The Veilguard.