Spider-Man: Brand New Day is set to post the biggest opening weekend of any film in 2026, according to early box office projections ahead of its release. Estimates from analysts vary widely but all point to a huge debut, arriving just two weeks after Christopher Nolan's The Odyssey, starring the same lead cast of Tom Holland, Zendaya and Jon Bernthal, set a high benchmark at the box office.

Deadline's more conservative estimate puts the domestic opening at $180-190 million, enough to surpass Toy Story 5's $159 million and claim the year's top spot, even with The Odyssey retaining exclusive access to IMAX screens. Box Office Pro is more bullish, forecasting $230-250 million domestically, which would make it the second-biggest Spider-Man opening ever behind No Way Home's $260 million. A separate global estimate suggests a $800 million worldwide opening weekend, which would rank second all-time behind Avengers: Endgame's $1.2 billion, though this figure is considered less certain.